Protocol Overview

Understanding and improving bone health

Regional Centres

Nine regional centres participated in this study.


Men and women, aged 25 years and older, recruited from 1995 to 1997, residing within a 50 km radius of one of nine designated clinical centres, contacted at random by phone.

Youth cohort: men and women, aged 16-24 recruited from 2004-2006.

Data Collection

At baseline, year 3 (for participants 40-60), year 5, year 10 and year 16 (for participants 60-75), a long questionnaire was administered to all consenting participants. A follow up mailed questionnaire was completed annually. Self reported fractures were confirmed by medical report or hospital discharge.

Bone density was measured using DXA (dual-energy X-ray absorptiometry) at the lumbar spine and hip, and ultrasound of the shin and wrist were taken.

Participants aged 50 years and older have had radiographs taken of the thoracic and lumbar spine. Blood, urine and DNA samples have been collected from participants in some centers at baseline, year 5 and year 10 follow-up. At year 16 follow-up, the participants aged 60 to 75 had radiographs taken of the thoracic and lumbar spine. Blood and DNA samples were collected from all consenting participants.

Meet our people

Dr. David Goltzman

Principal Investigator

The National Coordinating Centre is located in the McGill University Health Centre in Montreal. The coordinating centre is responsible for managing the study, developing the study’s material, and for data entry.

Claudie Berger

Chief Statistician

The Statistical Centre is located at the McGill University Health Centre in Montreal. This centre is responsible for carrying out the statistical analyses required to answer the medical and clinical questions that form the CaMos objectives, to carry out the analysis plan and report on the results.

Dr. W.P. Olszynski


The Ultrasound Imaging Centre is located in Saskatoon Osteoporosis Centre in Saskatoon.This centre receives the ultrasound data and is responsible for its analysis.

Whoever you are we work to improve your bone health